Principal Bioinformatics Scientist II
Company: F. Hoffmann-La Roche Gruppe
Location: Santa Clara
Posted on: October 8, 2024
Job Description:
Roche fosters diversity, equity and inclusion, representing the
communities we serve. When dealing with healthcare on a global
scale, diversity is an essential ingredient to success. We believe
that inclusion is key to understanding people's varied healthcare
needs. Together, we embrace individuality and share a passion for
exceptional care. Join Roche, where every voice matters.The
PositionA healthier future. It's what drives us to innovate. To
continuously advance science and ensure everyone has access to the
healthcare they need today and for generations to come. Creating a
world where we all have more time with the people we love. That's
what makes us Roche.Roche Sequencing Solutions (RSS), a business
within Roche Diagnostics, focused on developing a disruptive
Next-Generation Sequencing (NGS) platform along with a portfolio of
reagents, assays and informatics solutions for multiple disease
areas. We are looking for a Principal Bioinformatics Scientist in
the NGS Algorithms and Applications team to support the algorithm
development efforts.In this role, you will collaborate closely with
assay scientists, software engineers and other bioinformatics
scientists and apply your strong knowledge in next generation
sequencing technologies. This will include illumina SBS (sequencing
by synthesis), nanopore, etc. to design and develop algorithms for
read processing, alignment, and variant (SNV, SV,
insertions/deletions, CNV, TMB, MSI) callers etc. This will be used
in our products that will affect patient care.The Opportunity:
- Lead algorithm development effort for NGS applications
including conceptualization, method development and implementation
of production level algorithms in an Agile environment.
- Follow software development process and deliver and maintain
documentation that explains why and how as well as the final design
for scientific, marketing, and regulatory uses.
- Present internally or externally (peer-reviewed publications or
conference proceedings) and communicate updates across multiple
functions in the organization. Transfer algorithm to production
teams and provide scientific support for updates and
maintenance.
- Support bioinformatics pipeline to continue development for
existing products.Who You Are:
- You have a PhD in Bioinformatics, Computational Biology,
Computer Science, Statistics, Mathematics or other quantitative
field combined with 3+ years of industry/post-doc experience of
designing novel algorithms for NGS data analysis for example read
processing, variant calling (SNV, insertions/deletions, CNV, SV,
TMB, MSI etc.), variant annotation and analyzing large scale
complex genomic datasets.
- You have 2+ years of experience in developing novel algorithms,
complexity analysis, as well as demonstrated skills in statistical
and mathematical modeling.
- You have experience implementing high-quality and efficient
product level code.
- You have 2+ years of experience of sequencing (long and/or
short read), cancer molecular biology, bioinformatics tools,
statistical methods.
- You are proficient with programming languages (C++) in a
distributed Linux environment.
- You have hands-on experience using a workflow management system
such as Nextflow or Snakemake, using Docker and cloud computation
resource and storage.Preferred:
- You have one or more first/co-first author publication(s) in a
high-impact peer reviewed journals.
- You have experience with Machine learning / Deep learning (used
in NGS context).The expected salary range for this position based
on the primary location of Santa Clara, CA is 134,800-250,300.
Actual pay will be determined based on experience, qualifications,
geographic location, and other job-related factors permitted by
law. A discretionary annual bonus may be available based on
individual and Company performance. This position also qualifies
for the benefits detailed at the link provided below.Relocation
benefits are not available for this position.Who we areAt Roche,
more than 100,000 people across 100 countries are pushing back the
frontiers of healthcare. Working together, we've become one of the
world's leading research-focused healthcare groups. Our success is
built on innovation, curiosity and diversity.Roche is an equal
opportunity employer and strictly prohibits unlawful discrimination
based upon an individual's race, color, religion, gender, sexual
orientation, gender identity/expression, national origin/ancestry,
age, mental/physical disability, medical condition, marital status,
veteran status, or any other characteristic protected by law.If you
have a disability and need an accommodation in relation to the
online application process, please contact us by completing this
form .
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Keywords: F. Hoffmann-La Roche Gruppe, Santa Cruz , Principal Bioinformatics Scientist II, Other , Santa Clara, California
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